| Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids | |
Hao, Yinjing1; Lv SQ(吕守芹)2,3 ; Li W(李旺)2,3; Long M(龙勉)2,3; Cui, Yuhong1
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| Corresponding Author | Long, Mian(mlong@imech.ac.cn) ; Cui, Yuhong(yhcui@tju.edu.cn) |
| Source Publication | BIOMICROFLUIDICS
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| 2022-09-01 | |
| Volume | 16Issue:5Pages:12 |
| Abstract | In fatty liver diseases, such as liver fibrosis and liver cirrhosis, blood flow in hepatic sinusoids, an elementary building block of the liver lobule, tends to bypass through collateral vessels inside sinusoids and presents distinct sinusoidal flows compared to normal physiological flows. It remains unclear in those flow characteristics in branched sinusoids and the correlation of pathological flows with liver lesions, mainly due to the difficulty of direct hemodynamics measurements in the sinusoids. Here, we developed a dual-branched theoretical model of hepatic sinusoidal flow to elucidate the relevant flow dynamics and mass transport. Numerical simulations, based on the lattice Boltzmann method, indicated that the flow velocity distribution in hepatic sinusoids is mainly dominated by endothelium permeability and presents a non-monotonic variation with the permeability at the fusion segment of these branched sinusoids. Flow-induced shear stress on the endothelium at the side of the Disse space exhibited a biphasic pattern, yielding a low shear stress region at the junctional site. Meanwhile, a highly polarized distribution of lipoproteins concentration was also presented at the low shear stress region, indicating a localized accumulation of typical hepatic serum proteins. Thus, this work provides the basic understanding of blood flow features and mass transport regulations in branched hepatic sinusoids. Published under an exclusive license by AIP Publishing. |
| DOI | 10.1063/5.0100911 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000876633500002 |
| WOS Keyword | BLOOD-FLOW ; LIPID-METABOLISM |
| WOS Research Area | Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics |
| WOS Subject | Biochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas |
| Funding Project | National Natural Science Foundation of China (NNSFC) ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation ; [11972252] ; [QYZDJ-SSW-JSC018] ; [17JCYBJC29300] |
| Funding Organization | National Natural Science Foundation of China (NNSFC) ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation |
| Classification | 二类 |
| Ranking | 1 |
| Contributor | Long, Mian ; Cui, Yuhong |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/90673 |
| Collection | 微重力重点实验室 |
| Affiliation | 1.Tianjin Univ, Dept Mech, Tianjin 300072, Peoples R China; 2.Chinese Acad Sci, Natl Micrograv Lab, Beijing Key Lab Engn Construct & Mechanobiol, Ctr Biomech & Bioengn,Key Lab Micrograv,Inst Mech, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Hao, Yinjing,Lv SQ,Li W,et al. Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids[J]. BIOMICROFLUIDICS,2022,16,5,:12. |
| APA | Hao, Yinjing,吕守芹,李旺,龙勉,&Cui, Yuhong.(2022).Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids.BIOMICROFLUIDICS,16(5),12. |
| MLA | Hao, Yinjing,et al."Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids".BIOMICROFLUIDICS 16.5(2022):12. |
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| Jp2022FA175_2022_Bip（3422KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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