| Effects of exercise on flow characteristics in human carotids | |
He XY(何心怡); Yang XL(杨晓雷)
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| Corresponding Author | Yang, Xiaolei(xyang@imech.ac.cn) |
| Source Publication | PHYSICS OF FLUIDS
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| 2022 | |
| Volume | 34Issue:1Pages:16 |
| ISSN | 1070-6631 |
| Abstract | Carotid is one of the focal regions prone to atherosclerosis. Previous studies have shown that hemodynamics plays an important role in the initiation and formation of atherosclerosis plaques. In this work, we numerically investigate the flow patterns in two carotids with different flares and proximal curvatures under inflows from three age groups with/without exercise. The simulation results show that the effects of exercising on the carotid flow and wall shear stress are different at different time instants and for different age groups. As for the oscillatory shear index, exercise does not have significant effects. The effects of inflow waveforms on the reversed flow volume are also examined. For the carotid C1 with low flare and high proximal curvature, it is found that exercising increases and decreases the reversed flow volume for young and senior people, respectively. For middle-aged people, on the other hand, the reversed flow volume is increased and decreased in the middle of the sinus and near the bifurcation, respectively, for the carotid C1. For the carotid C2 with high flare and low curvature, on the other hand, it is found that exercising increases the reversed flow volume for all age groups. This work suggests that the effects of exercise on atherosclerosis should be evaluated by fully considering patient-specific geometries and ages. |
| DOI | 10.1063/5.0078061 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000753213600006 |
| WOS Keyword | ENDOTHELIAL GENE-EXPRESSION ; FLUID-STRUCTURE INTERACTION ; EPIGENETIC DNA METHYLATION ; IMMERSED BOUNDARY METHOD ; NITRIC-OXIDE PRODUCTION ; LARGE-EDDY SIMULATION ; SHEAR-STRESS ; BIFURCATION GEOMETRY ; ATHEROSCLEROSIS ; ARTERY |
| WOS Research Area | Mechanics ; Physics |
| WOS Subject | Mechanics ; Physics, Fluids & Plasmas |
| Funding Project | NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics[11988102] |
| Funding Organization | NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics |
| Classification | 一类/力学重要期刊 |
| Ranking | 1 |
| Contributor | Yang XL |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/88603 |
| Collection | 非线性力学国家重点实验室 |
| Recommended Citation GB/T 7714 | He XY,Yang XL. Effects of exercise on flow characteristics in human carotids[J]. PHYSICS OF FLUIDS,2022,34,1,:16. |
| APA | 何心怡,&杨晓雷.(2022).Effects of exercise on flow characteristics in human carotids.PHYSICS OF FLUIDS,34(1),16. |
| MLA | 何心怡,et al."Effects of exercise on flow characteristics in human carotids".PHYSICS OF FLUIDS 34.1(2022):16. |
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| File Name/Size | DocType | Version | Access | License | ||
| Jp2022FA565_2022_Eff（9512KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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