| Flow dynamics analyses of pathophysiological liver lobules using porous media theory | |
Hu JR(胡锦荣); Lv SQ(吕守芹) ; Feng, Shiliang; Long M(龙勉); Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China.; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
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| Source Publication | ACTA MECHANICA SINICA
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| 2017-08-01 | |
| Volume | 33Issue:4Pages:823-832 |
| ISSN | 0567-7718 |
| Abstract | Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule, is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvasculature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D computational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic, and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts (PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules. Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow features in cirrhotic lobules. Pressures, average velocities, and volume flowrates were profiled and the predictions compared well with experimental data. This study furthered our understanding of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules. |
| Keyword | Cirrhotic Liver Structural Distortion Portal Hypertension Collateral Vessels |
| DOI | 10.1007/s10409-017-0674-7 |
| Indexed By | SCI ; EI ; CSCD |
| Language | 英语 |
| WOS ID | WOS:000406348600013 |
| WOS Keyword | HEPATIC BLOOD-FLOW ; MATHEMATICAL-MODEL ; MICROCIRCULATION ; CIRRHOSIS ; FIBROSIS ; DISEASE |
| WOS Research Area | Engineering ; Mechanics |
| WOS Subject | Engineering, Mechanical ; Mechanics |
| Funding Organization | National Natural Science Foundation of China(31230027 ; Frontier Science Key Project of Chinese Science Academy(QYZDJ-SSW-JSC018) ; 91642203 ; 31661143044) |
| Department | NML分子-细胞生物力学与空间生命科学 |
| Classification | 二类 |
| Ranking | 1 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/60920 |
| Collection | 微重力重点实验室 |
| Corresponding Author | Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China.; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China. |
| Recommended Citation GB/T 7714 | Hu JR,Lv SQ,Feng, Shiliang,et al. Flow dynamics analyses of pathophysiological liver lobules using porous media theory[J]. ACTA MECHANICA SINICA,2017,33,4,:823-832. |
| APA | 胡锦荣,吕守芹,Feng, Shiliang,龙勉,Long, M ,&Long, M .(2017).Flow dynamics analyses of pathophysiological liver lobules using porous media theory.ACTA MECHANICA SINICA,33(4),823-832. |
| MLA | 胡锦荣,et al."Flow dynamics analyses of pathophysiological liver lobules using porous media theory".ACTA MECHANICA SINICA 33.4(2017):823-832. |
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| JouArt-2017-086.pdf（1617KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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